Furthermore, the persistent inflammatory environment driven by inflammasomes consumes local oxygen, creating an anaerobic microenvironment in the gut that alters the microbial ecology and may contribute to the development of related diseases (e.g., inflammatory bowel disease, colorectal cancer) (Li et al., 2026)
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It influences several overlapping repair pathways simultaneously: it may promote new blood vessel growth (VEGF), modulate the nitric oxide system, support collagen synthesis, and protect gut mucosal tissue
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